Bioinformatics

Classification of Autism Spectrum Disorder Using a 3D-CNN Ensemble Model and Regional Homogeneity Data from the ABIDE I Dataset

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication and social interaction, and presence of repetitive behaviors, and …

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Guilherme Bauer-Negrini

A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder

Background Autism Spectrum Disorder (ASD) is a neurodevelopmental condition estimated to affect 1% of individuals worldwide. Its etiology is still not fully understood, but several …

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Guilherme Bauer-Negrini

Usability evaluation of circRNA identification tools: Development of a heuristic-based framework and analysis

BACKGROUND AND OBJECTIVE: Circular RNAs (circRNAs) are endogenous molecules of non-coding RNA that form a covalently closed loop at the 3' and 5' ends. Recently, the role of these …

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Guilherme Bauer-Negrini
Usability evaluation of circRNA tools featured image

Usability evaluation of circRNA tools

This repository contains files to reproduce the heuristic evaluation environment described in the paper “Usability evaluation of circRNA identification tools - Development of a …

Interaction Design Patterns for Bioinformatics featured image

Interaction Design Patterns for Bioinformatics

Interaction design patterns to help bioinformatics software developers to improve the productivity and efficiency of their design process.

The role of T-cells in neurobehavioural development: Insights from the immunodeficient nude mice

Mice homozygous for the nude mutation (Foxn1nu) are hairless and exhibit congenital dysgenesis of the thymic epithelium, resulting in a primary immunodeficiency of mature T-cells, …

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Guilherme Bauer-Negrini

Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by several alterations, including disorganized brain cytoarchitecture and …

Júlio Santos-Terra

Resveratrol prevents brain edema, blood–brain barrier permeability, and altered aquaporin profile in autism animal model

Autism spectrum disorder can present a plethora of clinical conditions associated with the disorder, such as greater brain volume in the first years of life in a significant …

Iohanna Deckmann
Automated miRDB custom target search featured image

Automated miRDB custom target search

Command-line tool to automate the search for microRNA targets in the miRDB base and extract the number of binding sites

Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism

Autism spectrum disorder (ASD) is characterized by deficits in communication and social interaction, restricted interests, and stereotyped behavior. Environmental factors, such as …

Mauro Mozael Hirsch