In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum
Dec 14, 2025·,,,
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0 min read
Douglas Teixeira Leffa
Guilherme Povala
Pamela C. L. Ferreira
João Pedro Ferrari-Souza
Guilherme Bauer-Negrini
Matheus Scarpatto Rodrigues
Livia Amaral
Firoza Z. Lussier
Marina Scop Medeiros
Carolina Soares
Cristiano Schaffer Aguzzoli
Arthur C. Macedo
Joseph Therriault
Pedro Rosa-Neto
Dana L. Tudorascu
Eduardo R. Zimmer
Bruna Bellaver
Tharick A. Pascoal

Authors
Biomedical Data Scientist
Computational neuroscientist working at the intersection of machine learning, biomedical
imaging, and human genetics in neurodegenerative disease. My work applies deep learning to
high-dimensional medical images, harmonizes imaging measurements across sites and acquisition
protocols, and integrates imaging with genomic, proteomic, and longitudinal clinical data to
characterise Alzheimer’s disease and related dementias, with particular focus on fluid and
imaging biomarkers of neurodegeneration.